UbcH6; active 10 ug

Code: 23-036 D2-231

Application

Ubiquitination Cascade Comoponent: E2

Active, full length, recombinant human UbcH6. N-terminal HA, 6His-tagged. For use in Enzyme Assays. Functions as an E2...


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Your Price
€295.03 EACH
€362.89 inc. VAT

Application

Ubiquitination Cascade Comoponent: E2

Active, full length, recombinant human UbcH6. N-terminal HA, 6His-tagged. For use in Enzyme Assays. Functions as an E2 enzyme in ubiquitination assays.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Ubiquitin-conjugating (E2) enzymes are characterized by the presence of a highly conserved ubiquitin-conjugating domain which accommodates ATP-activated ubiquitin (Ub) via a covalently linked thioester onto its active-site residue. E2 enzymes act via selective protein-protein interactions with the ubiquitin-activating E1 enzyme and ubiquitin ligase E3 enzymes and are able to differentiate effects on downstream substrates, either with a single Ub molecule or a Ub chain. While E3s are involved in substrate selection, E2s are the main determinants for selection of the lysine to construct Ub chains, which thereby directly control the cellular fate of the substrate.
UbcH6 has been shown to interact with a number of diverse E3 ligases, including RNF20/40, Trim32 and WWP2.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

Purified using immobilized metal affinity chromatography.

biological sourcehuman
manufacturer/tradenameUpstate®
NCBI accession no.NM_003341
Quality Level300, 100
technique(s)activity assay: suitable
UniProt accession no.P51965
This product has met the following criteria to qualify for the following awards:



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